Friday, 1 March 2013

Monocyte Activation Test

The EDQM is conducting a survey on the Monocyte Activation Test (MAT), as described in European Pharmacopoeia general chapter 2.6.14 to gather information from all users and to facilitate its routine application as an in vitro replacement for the Test for pyrogens (2.6.8).

The MAT works by predicting the human response to pyrogens on the basis of human fever rather than animal models. This test may be used as an alternative to the rabbit pyrogen test. The MAT can test for Gram-positive and Gram-negative organisms, other biological pyrogens (e.g., yeast) and parasitic and viral pyrogens.

Deadline for responses: 7 March. For details see EDQM.

Posted by Tim Sandle