Tuesday, 13 August 2013

Exposure to Subclinical Lipopolysaccharide

An interesting paper has been written by Wilbur Lew and colleagues relating to endotoxin exposure. The paper has been published in PLoS One and it is titled “Recurrent Exposure to Subclinical Lipopolysaccharide Increases Mortality and Induces Cardiac Fibrosis in Mice.”

The abstract reads:

“Circulating subclinical lipopolysaccharide (LPS) occurs in health and disease. Ingesting high fatty meals increases LPS that cause metabolic endotoxemia. Subclinical LPS in periodontal disease may impair endothelial function. The heart may be targeted as cardiac cells express TLR4, the LPS receptor. It was hypothesized that recurrent exposure to subclinical LPS increases mortality and causes cardiac fibrosis… Recurrent exposure to subclinical LPS increases mortality and induces cardiac fibrosis.”

For further details, see PLoS One.

Posted by Tim Sandle