An
interesting paper has been written by Wilbur Lew and colleagues relating to
endotoxin exposure. The paper has been published in PLoS One and it is titled “Recurrent
Exposure to Subclinical Lipopolysaccharide Increases Mortality and Induces
Cardiac Fibrosis in Mice.”
“Circulating
subclinical lipopolysaccharide (LPS) occurs in health and disease. Ingesting
high fatty meals increases LPS that cause metabolic endotoxemia. Subclinical
LPS in periodontal disease may impair endothelial function. The heart may be
targeted as cardiac cells express TLR4, the LPS receptor. It was hypothesized
that recurrent exposure to subclinical LPS increases mortality and causes
cardiac fibrosis… Recurrent
exposure to subclinical LPS increases mortality and induces cardiac fibrosis.”
Posted by Tim Sandle
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