To
characterize biopharmaceuticals, particularly monoclonal antibodies and
antibody-drug conjugates (ADCs), you need a complete toolbox of powerful tools.
The
key points:
- How light scattering works
- Current uses of light-scattering, such as:
- Determining absolute molecular weight
- Studying PEGylated proteins
- Characterizing antibody-drug conjugates
- Studying protein aggregation
- When to use light-scattering detection, and when to use mass spectrometry
- Why you should consider light-scattering to determine the drug-antibody ratio of antibody-drug conjugates, and for effective characterization of the chemical, thermal, and colloidal stability of ADCs
Posted by Tim Sandle
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