Research scientists have demonstrated how it is possible to suppress the resistance of fungi to antifungal drugs.
The research team found that octyl-rhodamine was the most effective among the tested dyes -- it outperformed all others in increasing the effects of the conventional antifungals. The scientists also explained how this happens. Alkyl rhodamines are actively ejected by the ABC-transporters from the cells, but, as these compounds are extremely hydrophobic, they are immediately captured again. As a result, ABC-transporters are deceived: they are fully engaged in pumping out alkylated rhodamines, so they have no capacity to pump such detrimental drugs as clotrimazole.
For further details see:
Posted by Dr. Tim Sandle