Friday, 12 August 2016

Addressing fungal resistance to antimycotic drugs

Research scientists have demonstrated how it is possible to suppress the resistance of fungi to antifungal drugs.

The research team found that octyl-rhodamine was the most effective among the tested dyes -- it outperformed all others in increasing the effects of the conventional antifungals. The scientists also explained how this happens. Alkyl rhodamines are actively ejected by the ABC-transporters from the cells, but, as these compounds are extremely hydrophobic, they are immediately captured again. As a result, ABC-transporters are deceived: they are fully engaged in pumping out alkylated rhodamines, so they have no capacity to pump such detrimental drugs as clotrimazole.

For further details see:

Dmitry A. Knorre, Elizaveta Besedina, Iuliia E. Karavaeva, Ekaterina A. Smirnova, Olga V. Markova, Fedor F. Severin. Alkylrhodamines enhance the toxicity of clotrimazole and benzalkonium chloride by interfering with yeast pleiotropic ABC-transporters. FEMS Yeast Research, 2016; 16 (4): fow030 DOI: 10.1093/femsyr/fow030

Posted by Dr. Tim Sandle