Wednesday, 13 February 2019

Antibiotic resistance in the environment linked to fecal pollution


Increased levels of antibiotic resistant bacteria in the environment may have different causes. It could be a consequence of on-site selection from antibiotic residues in the environment, hence promoting the evolution of new forms of resistance. Alternatively, it is simply due contamination by fecal bacteria that often tend to be more resistant than other bacteria. Understanding which explanation is correct is fundamental to manage risks.

A new study shows that "crAssphage," a virus specific to bacteria in human feces, is highly correlated to the abundance of antibiotic resistance genes in environmental samples. This indicates that fecal pollution can largely explain the increase in resistant bacteria often found in human-impacted environments. There was, however, one clear exception where resistance genes were very common also without the presence of the phage -- environments polluted with high levels of antibiotics from manufacturing.


Joakim Larsson, Professor in Environmental Pharmacology at Sahlgrenska Academy, University of Gothenburg, and one of the co-authors, said: "These finding are important as they can inform management of human health risks associated with antibiotic resistant bacteria in the environment. While antibiotic residues is clearly the cause for the exceptionally high levels of resistance found near some manufacturing sites, fecal pollution is probably the explanation in most other places.

See:

Antti Karkman, Katariina Pärnänen, D. G. Joakim Larsson. Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-018-07992-3

Posted by Dr. Tim Sandle, Pharmaceutical Microbiology

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