Friday, 15 February 2019

Combatting drug resistant bacteria in intestines with new antibiotic


Clostridium difficile infection (CDI) is a potentially deadly infection in the large intestine most common in people who need to take antibiotics for a long period of time.

Researchers found when doses of a new antibiotic called Ramizol were given to hamsters infected with a lethal dose of the bacteria, a significant proportion of hamsters survived the infection.

In a recent safety study in rats evaluating the effect of repeated exposure of the antibiotic, no rats experienced serious side effects or changes in weight. Forty-eight rats were given a high dose of a new class of antibiotic for 14 days to assess its safety.

See:

Katherine Sibley, Jayson Chen, Lee Koetzner, Odete Mendes, Amy Kimzey, Janice Lansita, Ramiz A. Boulos. A 14-day repeat dose oral gavage range-finding study of a first-in-class CDI investigational antibiotic, in rats. Scientific Reports, 2019; 9 (1) DOI: 10.1038/s41598-018-36690-9

Posted by Dr. Tim Sandle, Pharmaceutical Microbiology

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