Tuesday, 29 October 2019

How mucosal infections can rewire an immune response to shape susceptibility to recurrence


A new study, published today in eLife.

The findings in mice reveal how mucosal infections, specifically bladder infections, can rewire inflammatory responses driven by a protein called tumour necrosis factor-alpha (TNFÉ‘) to impact susceptibility to recurrence. These results could inform the development of more effective new treatment strategies.

Scientists have shed new light on how mucosal infections can affect the body’s inflammatory response to shape susceptibility to recurrence.

Their study in mice reveals how recurrent mucosal infections, specifically bladder infections, can rewire inflammatory responses driven by a protein called tumour necrosis factor-alpha (TNFÉ‘) to impact susceptibility. The findings, published in eLife, could inform the development of effective new treatment strategies.

Mucosal bacterial infections, which include urinary tract infections (UTIs), are common. In the US alone, they account for over 42m outpatient visits and most of the 270m antibiotic prescriptions given to outpatients annually. Over 80% of UTIs are caused by uropathogenic Escherichia coli (UPEC), and the vast majority of these infections cause bladder infection. Previous data from female patients, who are disproportionately affected, suggest that their disease history may impact the nature of how UPEC interacts with their urinary tract mucosa, altering their susceptibility to future episodes.

For further details, see: eLife

Posted by Dr. Tim Sandle, Pharmaceutical Microbiology

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