Thursday, 7 November 2019

Blue laser light inhibits biofilm formation by inducing oxidative stress


An emerging, novel approach to control antibiotic-resistant bacterial infections is based on the use of light, in particular of blue wavelengths (400–470 nm). A new research paper of interest, concerning biofilm elimination by inducing oxidative stress. Here s the abstract:

Resolution of bacterial infections is often hampered by both resistance to conventional antibiotic therapy and hiding of bacterial cells inside biofilms, warranting the development of innovative therapeutic strategies. Here, we report the efficacy of blue laser light in eradicating Pseudomonas aeruginosa cells, grown in planktonic state, agar plates and mature biofilms, both in vitro and in vivo, with minimal toxicity to mammalian cells and tissues. Results obtained using knock-out mutants point to oxidative stress as a relevant mechanism by which blue laser light exerts its anti-microbial effect. Finally, the therapeutic potential is confirmed in a mouse model of skin wound infection. Collectively, these data set blue laser phototherapy as an innovative approach to inhibit bacterial growth and biofilm formation, and thus as a realistic treatment option for superinfected wounds.

The link to the research can be found here.

Posted by Dr. Tim Sandle, Pharmaceutical Microbiology

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