When
a patient is infected with a bacterial infection understanding and
administering the appropriate drug is of great importance. To select the
appropriate medication, antimicrobials must be selected and their effectiveness
demonstrated though controlled testing. Here, Antibiotic susceptibility testing
(AST) is conducted to determine which antibiotic will be most successful in
treating a bacterial infection in vivo. The detection of antimicrobial
substances is also an important part of drug discovery. This chapter discusses
the basis of the antimicrobial effectiveness test, as a mainstay of the
clinical microbiology laboratory. The chapter also considers tests for
preservative efficacy. Preservatives are added to some drug products in order
to suppress any microbial growth that might occur once the product begins to be
used by the consumer. The ability of these antimicrobial preservatives to
inhibit or kill microorganisms is evaluated using the antimicrobial
effectiveness test (AET).
Sandle,
T, (2016) Tests for Antimicrobial Effectiveness, Chesca, A. and Cengiz, M.
(Eds.) Theory and Practice for Medical
Diagnosis, Lambert Academic Publishing, Germany, pp7-19
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