Researchers have developed a way to
make extremely high-resolution images of tissue samples, at a fraction of the
cost of other techniques with similar resolution. Known as iterative expansion
microscopy, relies on expanding tissue repeatedly, before imaging it with a
conventional light microscope.
The new technique relies on expanding
tissue before imaging it with a conventional light microscope. Two years ago,
the MIT team showed that it was possible to expand tissue volumes 100-fold,
resulting in an image resolution of about 60 nanometers. Now, the researchers
have shown that expanding the tissue a second time before imaging can boost the
resolution to about 25 nanometers.
This level of resolution allows
scientists to see, for example, the proteins that cluster together in complex
patterns at brain synapses, helping neurons to communicate with each other. It
could also help researchers to map neural circuits.
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