Water-borne
microorganisms are ubiquitous and varied in their ability to survive and grow
under different conditions. Therefore, an out-of-control water system can cause
harm to the patient or adulterate pharmaceutical products. Purification of
water is required to prevent interaction with drug substances or other
ingredients in the product formulation. Water must also be microbiologically
controlled and monitored.
In
relation to this, Tim Sandle has written an article for Pharmaceutical
Engineering. The abstract reads:
This
article assesses some of the requirements for good design, together with the
control measures necessary to maintain effective microbiological control in
pharmaceutical facility water systems.
The
reference is:
Sandle,
T. (2017) Design and control of pharmaceutical water systems to minimize
microbial contamination, Pharmaceutical
Engineering, 37 (4): 44-48
Posted by Dr. Tim Sandle