Scientists have developed a workflow that enables large-scale,
genome-wide assays of gene importance across many conditions. The study,
'Mutant Phenotypes for Thousands of Bacterial Genes of Unknown Function,' has
been published in the journal Nature and is by far the largest functional
genomics study of bacteria ever published.
Tested on nearly three dozen bacteria from various genera, the
workflow combined high-throughput genetics and comparative genomics to identify
mutant phenotypes for thousands of genes with previously unknown functions.
The team worked with 32 bacteria, including plant-growth
promoting bacteria and a cyanobacterium relevant for biofuels production, as
well as bacteria involved in bioremediation.
The data set is publicly accessible for comparative analyses at
fit.genomics.lbl.gov, a web workbench developed by Morgan Price, the study's
lead author, who has also developed powerful tools such as PaperBlast to help
interpret results.
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