Burkholderia cepacia is the name for a
group or “complex” of bacteria that can be found in soil and water. B. cepacia bacteria are often resistant
to common antibiotics. In recent years there has been a series of product
recalls involving Burkholderia cepacia
complex (BCC).
To
address these concerns, pharmaceutical and healthcare manufacturers establish
procedures (e.g., sanitary design, equipment cleaning, environmental
monitoring) to prevent contamination of non-sterile drug products.
This
topic has been covered in a new book chapter, written by Tim Sandle. An
abbreviated abstract is:
This
chapter discusses the general characteristics of the BCC group. This is followed
by a review of the potential points of origin in pharmaceutical environmet6s,
which are generally low-nutrient environments like water. This is followed by a
review of the potential risks to patients that the organism presents. Such
risks are contextualized in relation to patient population and product type.
The
reference is:
Sandle,
T. (2018): Burkholderia cepacia
complex: Characteristics, products risks and testing requirements. In Reber, D.
and Griffin, M. (Eds.) Microbial Control
and Identification, DHI/PDA books, River Grove, USA, pp197-230. ISBN
Number: 9781942911272
Posted by Dr. Tim Sandle, Pharmaceutical Microbiology
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