New
research shows that protein-based biosensors can detect the presence of a
desired enzyme target and respond by physically lighting up and enabling researchers
to immediately identify cells with increased overall enzyme yield.
The
new approach, which comes from Los Alamos National Laboratory, can be translated
to screening of metagenomic samples, rational enzyme design, or
directed
evolution of known enzymes. The technology is adaptable to a single enzyme, or
a pathway, or global optimization of an industrial strain.
Tim
Sandle has conducted an interview with Dr. Ramesh Jha of the Los Alamos
National Laboratory to discover more.
The
reference is:
Sandle, T. (2019) Creating ‘smart’ microbial bionsensors: An interview with a Los Alamos National Laboratory researcher, Pharmig News, 75, pp2-3
For details, contact Tim Sandle
Posted by Dr. Tim Sandle, Pharmaceutical Microbiology
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