Sunday, 23 February 2020

Role of Lactobacillus in Human Reproduction

The discovery of microbial communities inhabiting the whole female reproductive tract has challenged the traditional view of human fetal development in a sterile environment. Technical advances have facilitated the study of the bacterial microbiome in the upper and lower genital tract, as well as the role of such bacteria in women’s health and fertility.

Lactobacillus is a genus of Gram-positive, facultative anaerobic or microaerophilic, rod-shaped, non-spore-forming bacteria.

They are a major part of the lactic acid bacteria group (i.e., they convert sugars to lactic acid). In humans, they constitute a significant component of the microbiota at a number of body sites, such as the digestive system, urinary system, and genital system. In women of European ancestry, Lactobacillus species are normally a major part of the vaginal microbiota. Lactobacillus forms biofilms in the vaginal and gut microbiota, allowing them to persist during harsh environmental conditions and maintain ample populations. Lactobacillus exhibits a mutualistic relationship with the human body, as it protects the host against potential invasions by pathogens, and in turn, the host provides a source of nutrients. Lactobacillus is the most common probiotic found in food such as yogurt, and it is diverse in its application to maintain human well-being, as it can help treat diarrhea, vaginal infections, and skin disorders such as eczema.

The microbiota in the urogenital tract of healthy reproductive age women is mainly composed of bacteria from the Lactobacillus genus; however, structural or compositional variations of this microbiota, that could occur throughout a women’s life in response to intrinsic and extrinsic factors may impact the function of reproductive organs leading to infertility or other pathological conditions.

Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (

No comments:

Post a Comment

Pharmaceutical Microbiology Resources

Special offers