Saturday, 2 May 2020

Specific gut bacteria may be associated with pulmonary arterial hypertension


Researchers have identified a distinct collection of bacteria found in the gut that may contribute to and predict the development of pulmonary arterial hypertension (PAH), according to new research.

PAH is a chronic and progressive disease in which the arteries that supply blood to the lungs are constricted, resulting in symptoms such as shortness of breath, heart palpitations, fatigue and others. In PAH, persistently high blood pressure in lung arteries makes the right side of the heart work too hard to pump blood, resulting in right-sided heart failure (inability of the heart to pump blood adequately). It is much less common than systemic blood pressure, which represents the force of blood moving through blood vessels throughout the entire body.
Everyone has a collection of bacteria in their gut -- known as microbiota -- that aid in digestion. The researchers found that having a specific microbiota profile in their gut predicted the presence of PAH with 83% accuracy.

"We showed for the first time that specific bacteria in the gut are present in people with PAH. While current PAH treatments focus on the lungs, looking at the lung/gut axis could open the door to new therapies centered in the digestive system," said Mohan Raizada, Ph.D., lead study author and distinguished professor in the department of physiology and functional genomics at the University of Florida College of Medicine in Gainesville, Fla.
For the study, stool samples were collected from 18 PAH patients and 12 people without a history of cardiopulmonary disease. The microbiota DNA from the stool samples were isolated and sequenced. The testing revealed a group of bacteria unique in the PAH patients that were associated with PAH.


This is the first link between a specific collection of bacteria and pulmonary arterial hypertension. However, it is not the first time that gut bacteria have been connected to medical conditions. A variety of different gut microbiota profiles have been linked to a variety of cardiovascular diseases including high blood pressure.


If the results are validated in a larger study, the researchers said that the unique bacterial profile could help to diagnose PAH early, possibly replacing the invasive heart catheterization that is used today to diagnose the disease. Also, new types of treatment focused on altering the gut microbiome of PAH patients could be developed, providing new hope for halting the progression of the disease.

See:

Seungbum Kim , Katya Rigatto , Marcelo B. Gazzana , Marli M. Knorst , Elaine M. Richards, Carl J. Pepine , Mohan K. Raizada. Altered Gut Microbiome Profile in Patients With Pulmonary Arterial Hypertension. Hypertension, 2020 DOI: 10.1161/HYPERTENSIONAHA.119.14294

Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)

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