This leads onto a new study of interest.
This study aims
to test the microcidal effect of silver-killed E. coli O104: H4 and its supernatant against fresh viable cells
of the same bacterium and some other species, including E. coli O157: H7,
Multidrug Resistant (MDR)
Pseudomonas aeruginosa and Methicillin Resistant Staphylococcus aureus (MRSA). Silver-killed bacteria
were examined by Transmission Electron Microscopy (TEM). Agar well diffusion assay was used to
test the antimicrobial efficacy and durability of both pellet suspension and supernatant of silver-killed
E. coli O104:H4 against other bacteria.
Both silver-killed bacteria and supernatant showed prolonged
antimicrobial activity against the tested strains that extended to 40 days. The presence of adsorbed
silver nanoparticles on the bacterial cell and inside the cells was verified by TEM. Silver-killed bacteria
serve as an efficient sustained release reservoir for exporting the lethal silver cations. This promotes
its use as a powerful disinfectant for polluted water and as an effective antibacterial which can be
included in wound and burn dressings to overcome the problem of wound contamination.
Reference:
Posted by Dr. Tim Sandle,
Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)
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