Monday, 3 August 2020

Cancer biomarkers in HIV-infection patients with and without drug addiction

Pathogenesis of the connection of HIV-infection and cancer is a problem for medical professionals and presents an interesting area for research. The aim of the study was to investigate the level of cancer biomarkers in HIV-infected patients with a background of narcotic drugs use, via parenteral administration, and in HIV-infected patients without a similar background.

Akhmaltdinova, L.L., Azizov, I. S., Tyukhtina, Z. P., Serdyuk, L. I., Kozachenko, N.V., Sandle, T., Moraru, D. and Chesca, A. (2020) Cancer biomarkers in HIV-infection patients with and without drug addiction, Acta Medica Mediterranea, 36: 1129-1132

Researchers analyzed the serum from 30 HIV-positive injecting drug users and30 HIV-positive patients without drug addiction. A control group consisted of 30 healthy people (negative in screening for HIV-infection) and a comparison group of 23 patients with drug dependence but no HIV-infection. The researchers used the xMap method on Bioplex 3D with a set cancer biomarkers panel: sHER-2, sEGFR, sIL-6Rα, FGF, sVEGFR-2, PECAM1, PDGF AB/BB, G-SCF, sTIE2, SCF, sVEGFR-1, osteopantin.

The research revealed the increased levels of sHER-2, sEGRf, sIL-6RA, sVEGfr2, PECAM1, sTIE2 in all HIV-infected patients. SCF and FGF markers were increased only in injecting drug users (HIV+/HIV-). The drug addicts with HIV had the increased level of inflammatory markers sIL-6RA, PECAM 1, osteopantin and the level of HER-2.

This study of carcinogenesis biomarkers showed its own peculiarities in HIV-positive patients, including complications for those with drug addiction.

Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (

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