The latest issue of Nature Microbiology contains a series ofinteresting articles on the progressive development of microbiological science.
Among the highlights are:
High-throughoput metagenomics
A comprehensive comparative analysis by Treichel et al. showcases this strength and ability of high-throughput metagenomics in capturing strain-level bacterial diversity. Simultaneously, the authors warn about technical shortcomings related to sequencing depth and provide guidelines to circumnavigate them, highlighting the importance of careful oversight.
Transcriptomic approaches
A Review by Clatworthy et al. summarizes recent developments in bacterial single-cell transcriptomic approaches that provide high-resolution insights into bacterial heterogeneity and its physiological influence.
RNA sequencing
Ntekas et al. combined single-cell RNA sequencing and microscopy to spatially resolve host–microorganism interactions associated with tumours along the mouse gut.
Bacterial communities
Moraïs et al. exploit high-throughput proteomics to uncover granular details on bacterial behaviour in simple and complex communities. It allowed them to quantitatively determine that bacteria respond to each other via modulation of their protein content to establish metabolic complementarity.
Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)