Wednesday, 18 February 2026

Gut bacteria actively track nutrients to sustain microbiome balance


 Beneficial gut bacteria are not passive residents but actively sense chemical signals and move toward valuable nutrients to sustain the microbiome. The discovery reshapes understanding of microbial communication and nutrient sharing, with implications for digestive health, metabolic balance, and future microbiome-based therapies.

Here are three experts who have recently shared their insights about gut microbiome, bacterial receptors and microbial movement:

Dr. Abigail Basson Raffner:   Instructor of Research, Department of Nutrition, School of Medicine Instructor of Research, Digestive Health Research Institute Dr. Abigail Basson, PhD, RD, LD, is a registered dietitian and NIH-funded Instructor.  

Dahlia Marin: Dahlia Marin, RDN, LD, CGN is a Registered Dietitian Nutritionist, Licensed Dietitian & Certified Gastrointestinal Nutritionist. She uses her own health story and clinical experience in Medical Nutrition Therapy.

Good Gut LIVE Podcast | Married to Health

Good Gut LIVE by Married to Health highlights all of the connections to common health issues and your gut microbiome. Gut health is global health because the gut is connected to everything.

Michael Bass, M.D.: Dr. Bass is a diplomate of the American Board of Internal Medicine, with a sub-specialization in Gastroenterology and Hepatology. He believes technology can transform the current landscape of Healthcare. 

  • Soluble Fiber: A Key Supplement for Optimal Gut Health
    Dr. Bass emphasizes gut health's role in digestion and immunity. He recommends soluble fiber, like psyllium husk, for its benefits in feeding beneficial bacteria and improving stool consistency. "Supplements should support a foundation built on whole foods," he advises, highlighting the importance of lifestyle choices in maintaining gut health.

  • Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)

    Why Treating Mental Health and Addiction Separately Often Fails

    A man expressing sadness with his head in his hands. Image by Tellmeimok, CC BY-SA 4.0
     

    For decades, mental health treatment and addiction treatment were placed in separate boxes. Someone struggling with depression was sent one way. Someone struggling with substance use was sent to another. Too often, people were told they had to “fix” one problem before addressing the other.

    This approach may seem logical on the surface—but in real life, it often fails.

    Mental health and addiction are deeply connected. When they are treated separately, important pieces of the recovery puzzle are missed. Understanding why this happens is key to creating care that truly supports long-term healing.

     

    Mental Health and Addiction Are Closely Linked

    Mental health conditions and substance use disorders frequently occur together. This is known as co-occurring disorders or dual diagnosis.

    Acc/ording to the Substance Abuse and Mental Health Services Administration (SAMHSA), nearly 9.2 million adults in the U.S. experience both a mental health disorder and a substance use disorder in the same year.

    Common mental health conditions that co-occur with addiction include:

         Anxiety disorders

         Depression

         Post-traumatic stress disorder (PTSD)

         Bipolar disorder

         Chronic stress and emotional dysregulation

    These conditions do not exist in isolation. They influence each other every day.

     

    Why Separation Became the Norm

    Historically, addiction was viewed as a behavioral or moral problem, while mental health conditions were treated as medical or psychological issues. This led to two separate systems of care, often with different providers, philosophies, and treatment goals.

    In practice, this separation creates gaps:

         Mental health providers may feel unprepared to address substance use

         Addiction programs may avoid deeper emotional or trauma work

         Clients are left bouncing between systems without coordinated care

    The result is fragmented treatment that does not reflect how people actually experience their struggles.

     

    How Treating Addiction Alone Can Fall Short

    When addiction is treated without addressing mental health, people may achieve short-term sobriety—but struggle to maintain it.

    Unaddressed mental health symptoms can include:

         Persistent anxiety or panic

         Depression or hopelessness

         Trauma triggers

         Emotional overwhelm

    According to the National Institute on Drug Abuse (NIDA), untreated mental health conditions significantly increase the risk of relapse.

    If substances were being used to cope with emotional pain, removing them without offering healthier coping tools leaves a major gap. Stress returns. Symptoms intensify. Old patterns resurface.

     

    How Treating Mental Health Alone Can Also Miss the Mark

    Treating mental health while ignoring substance use can be just as limiting.

    Substances can:

         Interfere with therapy progress

         Disrupt sleep and mood regulation

         Increase impulsivity and emotional instability

         Reduce the effectiveness of medications

    According to NIDA, ongoing substance use can worsen mental health symptoms and reduce the success of mental health treatment.

    This can leave people feeling stuck—doing “all the right things” in therapy while still struggling to function.

     

    The Role of Trauma in Both Conditions

    Trauma often sits at the center of both mental health challenges and addiction.

    According to the Centers for Disease Control and Prevention (CDC), individuals with high exposure to adverse childhood experiences (ACEs) are significantly more likely to experience both mental health disorders and substance use problems later in life.

    When trauma is not addressed:

         Anxiety remains heightened

         Emotional regulation is difficult

         Substance use may continue as a coping response

    Treating trauma separately—or not at all—leaves the root cause untouched.

     

    Why Sequential Treatment Often Fails

    Many people are told they must:

    1. Get sober first
    2. Then address mental health

    Or:

    1. Stabilize mental health first
    2. Then address substance use

    This sequential approach can be unrealistic and discouraging.

    Mental health symptoms can make early sobriety harder. Substance use can make mental health stabilization difficult. Waiting to treat one condition delays healing for both.

    According to SAMHSA, integrated treatment—where both conditions are addressed together—leads to better engagement, improved stability, and lower relapse rates.

     

    What Integrated Treatment Does Differently

    Integrated treatment recognizes that people are whole, complex human beings—not a list of diagnoses.

    Instead of separating care, integrated programs:

         Treat mental health and addiction at the same time

         Use coordinated treatment planning

         Address trauma, stress, and coping skills together

         Provide consistent messaging and support

    This approach reduces confusion and creates a clearer path forward.

     

    Evidence-Based Therapies That Support Integrated Care

    Integrated treatment uses therapies that work across conditions.

    Cognitive Behavioral Therapy (CBT)

    CBT helps people understand how thoughts, emotions, and behaviors interact—supporting both mental health stability and recovery.

    Trauma-Informed Therapy

    Trauma-informed care prioritizes safety, trust, and choice, reducing shame and supporting emotional regulation.

    EMDR (Eye Movement Desensitization and Reprocessing)

    EMDR helps process unresolved trauma that contributes to both mental health symptoms and substance use.

    Group Therapy

    When facilitated with emotional safety, group therapy reduces isolation and builds connection.

    According to the American Psychological Association, integrated, trauma-focused therapies lead to better outcomes for people with co-occurring conditions.

     

    The Impact on Long-Term Recovery

    When mental health and addiction are treated together:

         Emotional triggers become manageable

         Coping skills strengthen

         Relapse risk decreases

         Quality of life improves

    A study published in the Journal of Substance Abuse Treatment found that individuals receiving integrated care had higher treatment retention rates and better long-term recovery outcomes than those receiving separate or sequential treatment.

    Recovery becomes more than abstinence—it becomes stability.

     

    What This Means for Families

    Families often feel confused when their loved one improves briefly, then struggles again. This cycle can happen when treatment addresses only part of the problem.

    Integrated care helps families:

         Understand the full picture

         Reduce blame and frustration

         Learn how mental health and addiction interact

         Support lasting recovery

    According to SAMHSA, family involvement improves outcomes when treatment addresses both conditions together.

     

    A More Compassionate Model of Care

    Treating mental health and addiction separately often fails because it does not reflect real human experience.

    People do not struggle in neat categories. They struggle with pain, stress, trauma, and survival—all at once.

    Integrated, trauma-informed care offers a more compassionate and effective path forward.

     

    Healing Is Possible with the Right Approach

    When mental health and addiction are treated together, recovery becomes more sustainable and humane.

    People are no longer asked to choose which part of themselves deserves care. They are supported as whole individuals—with dignity, understanding, and hope.

     

    Sources

    1. Substance Abuse and Mental Health Services Administration (SAMHSA) – Co-Occurring Disorders
      https://www.samhsa.gov/mental-health/substance-use-co-occurring-disorders
    2. National Institute on Drug Abuse (NIDA) – Comorbidity
      https://nida.nih.gov/research-topics/comorbidity
    3. Centers for Disease Control and Prevention (CDC) – Adverse Childhood Experiences (ACEs)
      https://www.cdc.gov/violenceprevention/aces
    4. American Psychological Association (APA) – Integrated Treatment
      https://www.apa.org/monitor/2016/06/co-occurring
    5. Journal of Substance Abuse Treatment – Integrated Care Outcomes
      https://www.sciencedirect.com/science/article/pii/S0740547216303906

     

     

    Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)

    Friday, 13 February 2026

    23rd Annual Global Biopharma Manufacturing and Trends Analysis 2026


     The power of biotechnology...

    BioPlan conducts biopharma industry's most comprehensive global benchmarking analysis, and we need your participation. For over 20 years we've analyzed advances in bioprocessing, new technologies and emerging trends, and your feedback is crucial!

    For all completed and qualified surveys, you'll receive a copy of the summary results, along with an honorarium. Click here continue.

    Tim Sandle's microbiology website:- microbiology now!

     Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)

    Tuesday, 10 February 2026

    Floor Surface Contamination in Controlled Environments: A Change in Mindset


    Objectives

    • Evaluation argument for contamination control at the floor level
    • Including the floor level in a holistic view of the contamination control process

    The Story

    Studies in the late 1960’s – 1970’s demonstrated that redistribution of bacteria into the air from the floor accounted for up to 15% of all airborne bacteria (Hambraeus et al. 1978) and disinfection alone is short lived given the rapid rate of recontamination on vast surface such as the floor (Ayliffe, 1967).

    Current evidence surrounding floors as a key surface discusses how it may act as a reservoir in the chain of infection both in sensitive environments and potentially in other facilities as well.

    The 2000’s started to paint a clearer picture of how floor surfaces acted as vectors of re-dispersion for microbes (Gupta, 2007). The evidence consistently points in the direction of floors playing a role in pathogen dissemination, especially dust particles (Prout, 2013). Backing earlier research linking the risk of human shedding issues (Hambraeus, 1978) & their pathogenic risk if airborne (Wei, 2016).

    While there is limited research being developed on floor level controls outside of the healthcare setting, it is generalized as a relegated entity within a contamination control practice versus other surfaces.

    The Science

    The largest surface area in each room is seeing the least control across a variety of industries ….

    Touch level and air surface cleanliness alone are not sufficient practices based on the criticality of the areas they are positioned in. At best, one of the most basic requirements in controlled environments, shoe covers,  can themselves be a new vector of concern due to cross contamination between zones.

    Define Vectors – A vector is a path for contamination to travel with minimum disruption or control through wheels, shoes and the surfaces as a whole

    More people + more capacity + more activity = more particles + more risk = more control

    Most end users spend 80% of budget/time/effort on 20% of a problem when a reversal can yield more sustainable, long-term gains.

    Floor level control reduces substantial risk prior to controlled entry in a far more sustainable way.

    The ‘Sense’

    Cases explored and the Onion.

    The five second rule might apply in your kitchen, but it does not apply in sensitive manufacturing.

    The following diagrams represent a concept presented by Dr. Tim Sandle, he calls it the onion concept. This concept illustrates the most critical area, the one you want to keep free of contamination at the center of the diagram. This could be a cleanroom, controlled environments, and/or high-care settings. The critical center area is protected by the outer layers (or other areas) that surround it. Certain measures are put in place in these outer layers to prevent contamination from entering the critical area, this can include hand washing, gowning and contamination control flooring. As personnel move through each layer, it becomes cleaner and cleaner until they reach the critical area in the center. Depending on the criticality of the site, it will determine how many layers or areas there are to move through before reaching the center.

    You can see below a diagram of how particles at floor level may travel through each layer, the red particles show the general risk and most contamination comes from the outer layers inwards. The larger particles tend to be prevented earlier on and less particles are transferred as you move through the layers.

    A selection of settings where this is applicable…

    The Suggestion

    Dycem Contamination control flooring alternatives.

    The Statement

    Moving forward, what influence will floors have on contamination control?

    As Floors are a surface of high transmission, the contamination risk merits wider, more comprehensive research to value its part in a contamination control strategy (CCS). Part of this research considers the floor as a priority ‘vector surface’ to allow it to share equal weight in developing a CCS. If floors are treated for particulate control at the source of contamination, they can offer an exhaustive list of benefits for critical and controlled settings. Practitioners of CCS should approach the topic with a more holistic view to develop a CCS as part of their day-to-day, good manufacturing practices (GMP).

    Dycem has vastly improved cross-contamination reduction through its ability to be unavoidable, simple, and a long-term, effective solution.

    Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)

    Sunday, 8 February 2026

    Cleaning and disinfection techniques


    Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)

    Monday, 2 February 2026

    An appreciation


     

    Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)

    Best Merck webinars - 2025


     

    Missed an interesting webinar recently? Check out this list of high quality webinars from Merck:

    New EN ISO 7218 on General Requirements and Guidance for Microbiological Examinations in the Food Chain_Session 1

    Updated standards for laboratory quality and compliance.
    Watch Now >>

    Ecomapping® – A Practical Approach to Implement Sustainability in Your Lab

    Practical methods to optimize resource use and sustainability.
    Watch Now >>

    Green Chemistry as the Foundation of Sustainability and the Circular Economy

    Principles and applications of eco-friendly chemical synthesis.
    Watch Now >>

    The Art of Filtration 3.0

    Advances in filtration technology for sample preparation.
    Watch Now >>

    Revolutionizing Therapeutic Development with Patient-Centric Models

    Innovative cell culture models transforming drug development.
    Watch Now >>

    Expert Perspectives: Balancing Time and Contamination Risks in Sterility Testing

    Strategies for contamination risk management and timelines.
    Watch Now >>

    The Power of Foundations – The Basics of IHC

    Essential immunohistochemistry fundamentals.
    Watch Now >>

    Getting Equipped for the Future with the New MAS-100 Sirius® Microbial Air Sampler

    Latest equipment innovations for pharmaceutical production.
    Watch Now >>

     

     

    Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)

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