Monday, 7 August 2023

Continuous-flow manufacturing of essential antibiotic cefazolin: Flexible production while reducing costs


 

The antibiotic cefazolin is an essential drug according to the World Health Organization (WHO). It is usually produced via batch manufacturing, but this multistep process is time-consuming, wasteful and requires very specialized facilities.

 

Cefazolin is a broad-spectrum cephalosporin antibiotic mainly used for the treatment of skin bacterial infections and other moderate to severe bacterial infections in the lung, bone, joint, stomach, blood, heart valve, and urinary tract. The drug is effective against non-resistant forms of:

 

·         Staphylococcus aureus (including beta-lactamase producing strains)

·         Staphylococcus epidermidis

·         Streptococcus pyogenes,

·         Streptococcus agalactiae,

·         Streptococcus pneumoniae and other strains of streptococci

·         Escherichia coli

·         Proteus mirabilis

·         Klebsiella pneumoniae

 

Researchers have manufactured cefazolin using the continuous-flow method. This method is cheaper, quicker, less wasteful and more flexible in terms of how much drug can be produced when it is needed. As with most drugs, cefazolin is made via batch manufacturing, a step-by-step process enabling precise control at each stage. Due to the time frame, specially equipped and controlled space, and large amount of waste, production costs are not inexpensive and are particularly high when setting up new facilities.

 

An alternative to batch manufacturing is continuous-flow manufacturing. This method had not widely been used by drugmakers because it is more challenging to control the reactions taking place. However, researchers at the University of Tokyo have now developed a way to safely create cefazolin through continuous-flow manufacturing

 

Demand for this antibiotic fluctuates wildly and it is a drug that is better to not prepare too far in advance due to its instability. The benefit of the continuous-flow method is that it is easy to adjust the production volume as needed.

 

Continuous-flow manufacturing does not require pauses in between multiple individual steps, unlike the batch method. The researchers used two connected reactors to produce cefazolin from readily available commercial raw materials. The raw materials and reagents, which facilitate the reaction, were pumped into the first reactor, which looks like a coiled thin metal tube, before moving into a second reactor where another raw material was added. From there flowed the cefazolin.

 

The challenge was in optimising the environment inside the reactors, such as the temperature, transfer speed and mixing ratio of reagents, etc., to be able to obtain a high-purity product at the end, particularly due to the complex structure of cefazolin.

 

Many compounds can be synthesized by continuous-flow methods. By adopting this method, it is possible to produce a more stable drug supply, respond to rare diseases and disasters, and aid new drug development.

 

See:

 

Shoichi Sugita, Haruro Ishitani, Shū Kobayashi. A Practical and Convenient Synthesis of the Essential Antibiotic Drug Cefazolin under Sequential One-Flow Conditions. Bulletin of the Chemical Society of Japan, 2023; 96 (8): 744

 

Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)

Sunday, 6 August 2023

Clear Skin Ahead: 5 Best Cystic Acne Treatments


 

Acne is a common issue affecting both men and women, especially during the adolescent years. However, those who have experienced cystic acne would agree that it is a whole different ballgame. It's characterized by the development of red, swollen, and pus-filled pimples that can be incredibly painful. Cystic acne is the most severe form of acne, and if left untreated, it could lead to scarring. Fortunately, various treatments can help combat this skin condition. This blog post will discuss the five best treatments for cystic acne.

 

By Lizzie Weakley

 

Topical Retinoids

Retinoids such as tretinoin, adapalene, and tazarotene are commonly prescribed by dermatologists to combat cystic acne. Topical retinoids control the build-up of dead skin cells, which can clog pores and lead to acne. They also help reduce inflammation and boost collagen production, making them perfect for treating acne and preventing scarring.

 

Oral Antibiotics

Oral antibiotics such as tetracycline, erythromycin, and doxycycline are often prescribed to patients with inflamed acne. Using these antibiotics helps reduce inflammation and bacterial infection that causes acne. Typically, it takes 8 - 12 weeks of consistent use to see improvement in the skin's condition.

 

Isotretinoin

Isotretinoin, also known by its brand name Accutane, is an oral medication that's highly effective when it comes to treating acne. It's often the last resort for patients who don't see any improvement despite other acne treatments. Isotretinoin works by reducing sebum production, which leads to fewer pimples and less severe acne. It's worth noting that isotretinoin comes with potential side effects such as dry skin, muscle aches, and joint pain, among others.

 

Chemical Peels

Chemical peels have been around for decades and are becoming increasingly popular as an acne treatment. A chemical peel involves applying a chemical solution to the face, causing the skin to blister and peel off, revealing fresh and clear skin underneath it. Chemical peels also work by reducing the production of sebum and are effective in unclogging pores and treating acne scars, making it one of the best skin rejuvenation treatments.

 

Laser Treatments

Laser treatments such as Fraxel and Smoothbeam can help treat acne by targeting the oil-producing glands underneath the skin, reducing their activity. Additionally, laser treatments help boost collagen production, leading to the development of clearer and smoother skin. Laser treatments are a highly effective treatment for acne, but they may not be suitable for everyone. It's essential to consult a dermatologist to determine the best course of action.

 

Cystic acne can be frustrating and even embarrassing, but rest assured that there are various treatments available. The five best treatments for cystic acne include topical retinoids, oral antibiotics, isotretinoin, chemical peels, and laser treatments. Skin rejuvenation treatments are effective in treating acne scars and are often combined with acne treatment for the best results. It's crucial to consult a dermatologist to determine the best course of action for your skin to achieve clear and healthy skin.

 

Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)

Saturday, 5 August 2023

What are the Best Ways Pharma Can Fill the Skills Gap?


 

Pharmaceutical hiring is facing a severe skills shortage, but a few key strategies could help employers close the gap. By adjusting hiring practices and improving access to training, pharmaceutical companies can fill crucial roles while providing valuable jobs for thousands of people. What are the best tactics for filling the pharmaceutical skills gap? 

 

By Emily Newton

 

Fair and Flexible Experience Requirements

High barriers to entry in pharmaceutical hiring contribute to the skills shortage by keeping out candidates who may be skilled but lack experience. An increasing number of “entry-level” jobs require three or more years of experience, putting them out of reach of many actual entry-level candidates.

 

Employers can fill many positions left open by the skills gap by reconsidering the minimum required experience. This strategy is ideal for low-level jobs where on-the-job training would be feasible.

 

Applicants may have experience in other industries, have informal experience, be recent graduates or have an unfinished degree. Giving these applicants a chance may help fill many crucial roles while providing valuable career opportunities.

 

There is evidence for the effectiveness of rapid training programs, as well. For example, coding bootcamps have transformed hiring in computer science and cybersecurity roles.

 

Surveys show 31.7% of hiring managers have hired a coding bootcamp graduate, and 72.2% say those graduates performed as well or better than employees with a traditional bachelor’s degree. Interestingly, 71% of hiring managers specifically reported that coding bootcamp graduates were better at learning new skills quickly.

 

This data indicates that the type of job candidates who succeed in rapid training programs often have highly advantageous underlying skills or traits that can make them great employees. Furthermore, a lack of experience doesn’t necessarily mean an employee is less capable or skilled than someone with more experience.

Apprenticeship Programs and International Hiring

Apprenticeship programs are ideal for addressing pharmaceutical hiring because of today’s high need for specialized skill sets. Many university programs struggle to keep up with the rapid pace of change, leaving graduates ill-equipped to meet skill and experience requirements.

 

Apprenticeship programs close the gap by providing graduates with valuable skills and allowing employers to train employees for the exact skills they need. Running an apprenticeship program requires some investment, but it could pay off significantly for the entire industry.

 

A single job vacancy can cost thousands of dollars per month, with skills shortages overall costing businesses $8.5 trillion in the U.S. by 2030. In contrast, consider an apprenticeship program paying a recent graduate or graduate student for living expenses and a monthly stipend. Within six to twelve months, this student could learn the specialized skills the employer needs while also working for them.

 

The cost of paying for that student’s training through an apprenticeship could pay itself off within a year, especially if the apprentice continues working for their employer for several years afterward. Job loyalty is much more likely in a scenario like this, where employers show how much they value employees by investing in their careers.

Creating Opportunities for International Applicants

Pharmaceutical hiring managers can use apprenticeships to tap into hiring pools outside their usual range. For example, a pharmaceutical company might create an apprenticeship program in collaboration with a foreign university to provide immersive study-abroad opportunities. Students could experience another culture while learning valuable career skills and potentially securing a job.

 

International hiring requires some extra preparation, although it may be worth it to help close the skills gap by bringing talented people where they are needed most. That could even apply to domestic employees who may be able to fill a skills shortage at another office within the same company.

 

A robust global mobility strategy can improve retention rates by reducing geographic barriers to employment. Those barriers can be particularly challenging for students and recent graduates who may want to take a pharmaceutical job but lack the financial ability to relocate.

Collaboration with Universities

Working with universities can be a great long-term strategy for resolving pharmaceutical hiring challenges. Recent, ongoing innovations in the industry are making it challenging for university professors and resources to keep up. Many advanced technologies and pieces of equipment are completely beyond the financial reach of many educational institutions.

 

As a result, many new graduates are entering the pharmaceutical hiring pool with outdated skills and a lack of important specialized skills. Collaborating with universities to expand access to equipment, processes and resources could help resolve this issue. This could come in the form of apprenticeship programs built specifically for university students, much like an internship.

Reskilling, Upskilling and Mentorships

For people already working in the pharmaceutical industry, reskilling, upskilling and mentorships are the best option for addressing skill gaps. This typically includes workplace training programs focused on building new skills in existing employees, often with the goal of transitioning to a new role at the same company.

 

Reskilling and upskilling are good for employees as well as pharmaceutical companies. Studies show that skill building programs result in higher employee satisfaction and retention. Reskilling and upskilling may help prevent employees from quitting and worsening the industry’s labor shortage.

 

The main difference between reskilling and upskilling is the gap between an employee’s current and new roles. For instance, a pharmaceutical company might train an IT team member to work in AI process modeling. This would be upskilling since the IT team member is still working in a related role.

 

Reskilling is ideal for retaining workers if their current job becomes obsolete. For instance, a pharmaceutical manufacturer could reskill assembly line workers to become robotics technicians or programmers. Both reskilling and upskilling can resolve skill gaps, just in different ways.

Resolving Pharmaceutical Hiring Challenges

Pharmaceutical hiring managers are grappling with a serious skills shortage due to rapid innovation and change in the industry. Luckily, there are a few robust strategies employers can use to close the gap and get the skilled workforce they need. Expanding access to training and resources for both new and existing employees is the key to resolving the skills shortage today and in the long term.

 

Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)

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