Wednesday, 4 March 2015

Breathing in Bacteria

The healthy lung receives microbes from the mouth, a new model suggests.

The small community of bacteria that make up the lung microbiome isn’t particularly suited for the harsh environment, but rather reflects the composition of microbial species that live in the oral cavity and reach the lung via air flow, according to a study published in mBio.

Microbiome communities arise either by being selected for their adaptations to a particular environment or by drifting over to a new environment from a neighbouring one, a process known as neutral distribution. Since the lung microbiome is both relatively small—with typically 1,000-fold less microbial DNA than the amount isolated from the mouth—and well-connected to other microbial communities throughout the respiratory tract, a team led by scientists at the University of Michigan hypothesized that most of the bacteria residing in the lungs came from elsewhere. To test their idea, the scientists built a model of what the lung microbiome would look like if it were mainly made up of bacteria entering from the oral cavity and compared the model results to the actual microbial DNA composition of the lungs. The bacterial DNA they found in healthy lungs largely matched the pattern that would be expected from neutral distribution.

By contrast, the researchers found that in lung samples from patients with cystic fibrosis or pneumonia, the microbial populations did not fit the neutral distribution model, indicating that diseased lungs do put selective pressure on their microbial residents.

Source: The Scientist

Posted by Tim Sandle