An important factor related to this consideration, especially for when cleanroom equipment is selected, is the surface finish and surface roughness. This focus on topography is particularly useful for stainless steel given the commonality of this material, along with anodized aluminum, for the production of pharmaceutical processing equipment. Hence, specifying appropriate finishes and limits of roughness should form part of equipment and facility specifications, as informed by the principles of quality by design. The factors affecting finish and roughness are of importance in relation to microbial attachment and the pharmaceutical sector should develop appropriate equipment design specifications and User Requirement Specifications.
Tim Sandle's new paper:
Sandle, T. (2021) Microbial attachment and pharmaceutical equipment, American Pharmaceutical Review, 24 (6): 84-90
https://www.americanpharmaceuticalreview.com/1429-AuthorProfile/3441-Tim-Sandle-Ph-D/
Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)
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