The
microbiological impurities are the most critical ones in a water system and are
thus of special
concern. the design, operation and maintenance of pharmaceutical-grade water
systems is critical for ensuring suitable in-process control and final product
quality. The levels of microorganisms in the in-coming water can be hard to predict,
due to the variables of seasonality particularly for countries with temperate
climates), temperature, pH, velocity, stresses and heat, plus differences in
water system design between one facility and another. In case of contamination
of a purification unit or a distribution system, the user must react quickly.
The authors have written down their experience and explain details about the
typical microbiome of a water system. In addition, advice is given on how to remediate
microbial contamination.
Reference:
Roeder, F. and Sandle, T. (2022) Microbial Contamination in Water Systems, PDA Journal of Pharmaceutical Science and Technology, 76 (4): DOI: https://doi.org/10.5731/pdajpst.2021.012636
Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)
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