Meta-organism entangled metabolic pathway of microbial 3M3SH malodor biotransformation steered by human precursor thiol conjugate substrate in ABCC11 haplotypes.
A new microbiome study of interest.
The project concerns the evolutionary roots of human ancestral ethnic group global regionalizations, as involving skin niche microbial communities.
We address humans as “meta-organism” entities—i.e., entangled conglomerates of microbe genomes plus Homo sapiens genomes that have co-evolved through symbiotic mutualism.
The study asks the existential question: who is the evolutionary driver that steered modern humans into becoming such a meta-organism—was it people or microbes? How has survival advantage steered the ancient human origins of geographic regional clustering of ancestral ethnic groups with signature microbiomes?
Our data center on the key role of a microbe unique to humans, Staphylococcus hominis, and its engineering of “selfish gene” propagation opportunities by way of steering social interactions and communicable contacts among it’s human hosts whom are relegated as mere Trojan horse delivery vessels and incubators subserving their microbial companions. Within an extended family tree, this bacterial species is either inherited or not inherited by individuals, as governed by SNP variants of the human ABCC11 gene responsible for body odor vs. no odor binary pheromone communication.
The paper is:
Stevens, B.R., Roesch, L.F.W. Interplay of human ABCC11 transporter gene variants with axillary skin microbiome functional genomics. Nature Sci Rep 14, 28037 (2024).
Publisher’s link: https://doi.org/10.1038/s41598-024-78711-w .
You can jump to Fig. 6 for an overview lay summary.
A reprint PDF with additional Supplementary content is set out below:
Interplay of Human ABCC11 Transporter Gene Variants With Axillary Skin Microbiome Functional Genomic 2024 N... by Tim Sandle on Scribd
Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)
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