Friday, 28 February 2014

How bacteria evade antibiotics

A step forward has been made in understanding how a subset of bacterial cells escape being killed by many antibiotics. It appears that cells become "persisters" by entering a state in which they stop replicating and are able to tolerate antibiotics. Unlike antibiotic resistance, which arises because of genetic mutations and is passed on to later generations, this tolerant phase is only temporary, but it may contribute to the later development of resistance.

For further details, refer to the following research paper:

S. Helaine, A. M. Cheverton, K. G. Watson, L. M. Faure, S. A. Matthews, D. W. Holden. Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters. Science, 2014; 343 (6167): 204 DOI: 10.1126/science.1244705

Posted by Tim Sandle