Contamination control is the primary consideration in cleanroom design,however,the relationships between contamination control and airflow are not well understood.Contaminants such as particles or microbes are primarily introduced to cleanrooms by people,although processes in cleanrooms may also introduce contamination.
Based on these risk considerations, Tim Sandle has written a paper on a risk based approach to looking at cleanrooms and air quality. The paper is being hosted by the Irish Cleanrooms Society.
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Pharmaceutical Microbiology Resources