One
design aspect is with the incorporation of antimicrobial materials into
surfaces as a means to reduce microbial numbers (or at least to prevent
microorganisms from growing). This addition has become commonplace in many hospitals1
and within food factories;2 however, the adoption has been slower within
pharmaceuticals (where the use of antibacterial materials used to coat
cleanroom surfaces is sometimes referred to as “biotrunking”). A second design
aspect lies with the selection of surface properties of materials, so that
surfaces can reduce the possibility of microbial attachment, making
disassociated organisms easier to kill by disinfection. Combined, antimicrobial
surfaces with specific topography has the potential to reduce microbial
survival in cleanrooms.
In
relation to this, Tim Sandle has written an article. The reference is:
Sandle,
T. (2020) Minimizing microbial contamination on cleanroom surfaces, American
Pharmaceutical Review, 23 (2): 30-35
In
this article, different antimicrobial technologies together with physical
properties are considered together with a review of available literature to
examine the efficacy of such surface materials.
Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)
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