Tuesday 16 August 2022

What's All The Hype About mRNA Vaccinology?


The realization of medicines based on mRNA technology is a relatively recent breakthrough, with several products under trial. Moreover, the COVID-19 vaccine success is spurring a further stream of medicines to come. An mRNA-based medicine is a different concept; it does not fall into small molecule-based pharmaceuticals or within conventional biologics (recombinant proteins and monoclonal antibodies) but rather falls within the emergent field of nucleic acid therapeutics. mRNA medicines function like sets of instructions directed at human cells to make proteins to prevent or fight disease.


The application of mRNA technology came to the fore with the launch of the Pfizer/BioNTech and Moderna vaccines, designed to combat the SARS-CoV-2 virus responsible for COVID-19. Until this point, vaccines were either inactivated viruses designed to trigger the immune system, which is the case with most influenza vaccines, or vaccines comprising individual proteins.



Sandle, T. (2022) What's All The Hype About mRNA Vaccinology?, Pharmaceutical Online: https://www.pharmaceuticalonline.com/doc/what-s-all-the-hype-about-mrna-vaccinology-0001


Also BioProcess Online: https://www.bioprocessonline.com/doc/what-s-all-the-hype-about-mrna-vaccinology-0001

Also Outsourced Pharma: https://www.outsourcedpharma.com/doc/what-s-all-the-hype-about-mrna-vaccinology-0001


Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)

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