Changing rooms act as critical control points within pharmaceutical manufacturing facilities, functioning as microbial airlocks that limit personnel‑borne contamination entering classified processing areas. This study presents a five‑year comparative analysis (2022–2025) of microorganisms recovered from changing rooms and adjacent corridors, spanning cleanroom Grades D, C, and B.
Environmental monitoring data—comprising surface contact plates, settle plates, and active air samples—were analysed and microbial profiles were evaluated. Across all areas, Gram‑positive cocci dominated, especially Micrococcus, Kocuria, and coagulase‑negative Staphylococcus, consistent with human skin flora. Grade D changing rooms showed the highest overall bioburden and organism diversity.
Progressive reductions in microbial burden were observed as personnel transitioned through Grade C into Grade B areas. However, opportunities for improvement in gowning, cleaning, and moisture control were identified. This study provides a comprehensive dataset relating to pharmaceutical changing‑room microbiota and offers a reproducible framework for microbial profiling, trending, and benchmarking across cleanroom facilities.
To access, see: https://www.ejpps.online/post/comparative-analysis-of-pharmaceutical-facility-changing-room-microbiota
Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)
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