Glucans and the Bacterial Endotoxin Test

The issue of beta-glucans and the relationship of these substances to the LAL test remains an important area not described in great detail in compendial or regulatory documents. β-Glucans (beta-glucans) are polysaccharides of D-glucose monomers linked by β-glycosidic bonds. Glucans are important because they can react with certain lysates and cause interference with the LAL test.

In relation to this area of pharmaceutical concern, Tim Sandle has written an introductory paper. It can be accessed here: glucans.

Posted by Tim Sandle