Monday 20 September 2021

Study of fungi isolated from pharmaceutical cleanrooms: Types and origins

Understanding cleanroom microbiota is of importance for microbiologists and quality personnel to assess risks to products and to the environment, to propose remediation activities, to review changes in trends and to select representative organisms for growth promotion and disinfectant efficacy studies. Shifts with the types of organisms may indicate resistant strains, problems with cleaning practices and objectionable microorganisms. There are few published studies of the typical cleanroom microbiota and extraordinarily little information pertaining to fungi. This paper reviews fungi collected across a ten year period from EU GMP Grade C and D cleanrooms from a pharmaceutical facility. The paper considers the common types of fungi recovered and discusses their potential origins, in relation to people, indoor environments and outdoor environments (temperate oceanic climate). The most common genera of fungi isolates were: Aspergillus, Candida, Cladosporium, Fusarium and Penicillium.


Tim Sandle has written a new peer reviewed paper. The reference is:

 Sandle, T. (2021) Study of fungi isolated from pharmaceutical cleanrooms: Types and origins, European Journal of Parenteral and Pharmaceutical Science, 26(2):

 Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (


  1. Figure 6 of Candida and Figure 10 of Fusarium are the same picure.

  2. Do believe this information is transferable to "food made with cultured animal cell" industry?


Pharmaceutical Microbiology Resources

Special offers