Monday 3 January 2022

Addressing temperature and humidity fluctuations in cleanrooms


Temperature and humidity control are important factors to control within the cleanroom. For pharmaceuticals and healthcare products, this relates to three areas. The first is to avoid extremes affecting the skin of the operator, and hence the ability of the cleanroom gown to contain contamination. However, temperature and humidity are not independent factors and their interrelationship needs to be considered, in addition to airflow velocity, and the comfort levels experienced by operators themselves. For these reasons, a well-designed and maintained heating, ventilation, and air conditioning (HVAC) system  is  a  critical  part  of  pharmaceutical  cleanroom  design. By bringing together meteorological, environmental, clinical, and cleanroom data, it is possible to determine optimal parameters for the cleanroom.


This paper provides a humidex which can be used to assess temperature and humidity fluctuations in cleanrooms and controlled environments.


Sandle, T. (2021) A Humidex For The Cleanroom: Why Temperature And Humidity Control Matters, Journal of GxP Compliance, 25 (3):     DOI: 10.1080/21506590.25352021TS-HCWTHCM


Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (

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