Control of viruses within cleanrooms: A review of disinfectant agents

 

This paper identifies the risks of  contamination by viruses in the  manufacture of biopharmaceutical  products in cleanrooms. Different types  of viruses are described with non-enclosed viruses being more resistant to  disinfectants. Care should be taken as  many common disinfectants are only  suitable for bacterial or fungal  contamination. A table gives guidance on  the selection of appropriate disinfectant  types to deal with viral contamination.

 

 

Many types of viruses pose  contamination risks to biopharmaceuticals  during processing and the majority of  these will be located on cleanroom  surfaces. Outside of a host cell, viruses  cannot replicate. However, they can  survive on surfaces as viral particles  (virions). Most literature for  pharmaceutical manufacturing focuses  on disinfectants used to address  bacterial or fungal contamination. This article looks at the selection and factors  for success relating to disinfectants for  the control of viruses.

 

Sandle, T. (2023) Control of viruses within cleanrooms: A review of disinfectant agents, Clean Air and Containment Review, 49: 18-21

 

Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)