Sunday, 7 December 2014

How cells defend themselves against antibiotics

ABC Transporters are proteins that are embedded in the cell membrane and facilitate the transport across cellular barriers not only of an almost unlimited variety of toxic substances, but also of substances that are essential for life. They also play a role in the development of antibiotic resistance. A research group has now succeeded in elucidating the detailed structure of this transporter.

For details see:

JungMin Kim, Shenping Wu, Thomas M. Tomasiak, Claudia Mergel, Michael B. Winter, Sebastian B. Stiller, Yaneth Robles-Colmanares, Robert M. Stroud, Robert Tampé, Charles S. Craik, Yifan Cheng. Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter. Nature, 2014; DOI: 10.1038/nature13872

Posted by Tim Sandle