Saturday, 1 August 2015

New insights into biofilm formation

University of Maryland investigators have now shown that a "messenger molecule" produced by the opportunistic human pathogen, Pseudomonas aeruginosa, encourages bacteria to colonize catheters in the bladders of laboratory mice, where they form biofilms.

Normally, in the absence of the kinds of surfaces that encourage biofilm formation, there are few bacteria in either the bladder or the kidneys. In earlier work, these investigators showed--as numerous others had done--that the messenger molecule, cyclic-di-GMP (c-di-GMP) promotes biofilm formation when such surfaces are present.

For further details, see:

Stephanie J. Cole and Vincent T. Lee. yclic-di-GMP signaling contributes to Pseudomonas aeruginosa mediated catheter-associated urinary tract infection. Journal of Bacteriology, 2015 DOI: 10.1128/JB.00410-15

Posted by Tim Sandle