A major breakthrough in understanding how pathogenic microbes develop resistance to antibiotic drugs has been reported in Nature Communications. By examining combinations of seven mutations in dihydrofolate reductase that microbes can acquire to gain trimetoprim resistance, researchers found that evolution toward proceeds along less direct paths than might be expected, as cells range through a multipeaked adaptive landscape and delay commitment to a single genotypic fate.
Posted by Dr. Tim Sandle
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Pharmaceutical Microbiology