Tuesday, 22 October 2013

Beta glucans as pharmaceutical product impurities

β-Glucans (beta-glucans) are polysaccharides of D-glucose monomers linked by β-glycosidic bonds. Glucans are important because they can react with certain lysates and cause interference with the LAL test. Furthermore, glucans can, in certain circumstances, cause physiological effects in humans (β-glucans are known as “biological response modifiers” because of their ability to activate the immune system).

To discuss the implications on both the LAL test and in relation to pharmaceutical products, Tim Sandle has written an article for the American Pharmaceutical Review. The article has been published as a special supplement ‘Further Pharmaceutical Microbiology’.

The reference is:

Sandle, T. (2013). Pharmaceutical Product Impurities: Considering Beta Glucans, American Pharmaceutical Review, 16 (5) Supplement S1: 16-19

Posted by Tim Sandle