Sometimes,
unexplained results occur when using biological indicators. This could be
attributable to a failure of the sterilization process or, perhaps, due to a
mishandling of the biological indicator. Other reasons could be traced to
issues of resistance and variations with the biological indicator itself.
In
relation to this, Tim Sandle has written a paper which discusses the
“phenomenon of resistance” for the Journal of Validation Technology.
The
paper can be found here.
The
reference is:
Posted by Tim Sandle
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Pharmaceutical Microbiology Resources